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[EN] The present invention is drawn to methods for designing synthetic nucleotide sequences encoding polypeptides of interest. The methods involve organizing a database of sequences as a set of N-length oligomer sequences and compiling a list of probabili
Industry:
General
Inventor:
TOMSO DANIEL J (US)
The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an oxidizing environment.
Industry:
Life Sciences
Inventor:
Schwartz; Marc F.|Soliman; Tarik
Maize plants with reduced gene silencing are disclosed.
Industry:
Research
Inventor:
Stonaker; Jennifer L.|Hale; Christopher J.|Hollick; Jay B.
[EN] The present invention provides an improved system for linking nucleic acids to one another. In particular the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. Th
Industry:
General
Inventor:
JARRELL KEVIN A (US); TURCZYK BRIAN (US)
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limi
Industry:
Life Sciences
Inventor:
Smith; James Jefferson|Jantz; Derek|Hellinga; Homme W.
A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifyi
Industry:
Life Sciences
Inventor:
Maranas; Costas D.|Burgard; Anthony P.|Pharkya; Priti
[EN] Provided herein are genetically modified microorganisms that have enhanced fermentation activity and methods for making and using such microorganisms.\[FR] La présente invention concerne des micro-organismes génétiquement modifiés qui ont une activit
Industry:
Chemical
Inventor:
PICATAGGIO STEPHEN (US); SALMON KIRSTY ANNE LILY (US); LAPLAZA JOSE MIGUEL (US)
[EN] This invention relates to methods and systems for in silico or bioinformatic modeling of cellular metabolism. The invention includes methods and systems for modeling cellular metabolism of an organism comprising constructing a flux balance analysis m
Industry:
General
Inventor:
BURGARD ANTHONY P (US); MARANAS COSTAS (US)
Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, includi
Industry:
Life Sciences
Inventor:
Bauer; Keith A|Gelfand; David Harrow
The invention provides a non-naturally occurring microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (1,4-BDO) biosynthetic pathways. The pathways include exogenous nucleic acids encoding a) an ±-ketoglutarate decarboxylase; b) a 4-
Industry:
Research
Inventor:
NA
[EN] The invention provides a non-naturally occurring microbial organism having an pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate 6-aminocaproic acid or caprolactam pathway. The i
Industry:
Chemical
Inventor:
BURGARD ANTHONY P (US); PHARKYA PRITI (US); OSTERHOUT ROBIN E (US)
A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon f
Industry:
Chemical
Inventor:
NA
The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from about 101 to about 105 different sequences, generally betwee
Industry:
Research
Inventor:
McGall; Glenn H.|Kuimelis; Robert G.
[EN] Methods of recombining nucleic acids including homologous nucleic acids are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures as well as polymerase and ligase mediated recombination methods are also pr
Industry:
General
Inventor:
CRAMERI ANDREAS (CH); Stemmer Willem P. C. (US)
A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a
Industry:
Research
Inventor:
Maranas; Costas D.|Burgard; Anthony R.|Pharkya; Priti
The present teachings provide methods, compositions, and kits for synthesizing and sequencing nucleic acids. In some embodiments, reversible di-nucleotide compounds are employed along with cleaving reactions that remove a label and a blocking moiety. Impr
Industry:
Research
Inventor:
Zon; Gerald
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal p
Industry:
Research
Inventor:
Schultz; Peter G.|Wang; Lei|Anderson; John Christopher|Chin; Jason W.|Liu; David R.|Magliery; Thomas J.|Meggers; Eric L.|Mehl; Ryan Aaron|Pastrnak; Miro|Santoro; Stephen William|Zhang; Zhiwen
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsyn-thetases, pairs of
Industry:
Life Sciences
Inventor:
Deiters; Alexander|Cropp; T. Ashton|Chin; Jason W.|Anderson; J. Christopher|Schultz; Peter G.
The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
Industry:
General
Inventor:
Cox III George N.
[From equivalent EP1482046A3] Provided herein are granulocyte colony stimulating factor (“G-CSF”) analogs, compositions containing such analogs, and related compositions. In another aspect, provided herein are nucleic acids encoding the prese
Industry:
Research
Inventor:
Osslund, Timothy