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Genetically engineered microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use
Industry:
Energy
Inventor:
CHURCH GEORGE (--); KEASLING JAY D (--); SOMMERVILLE CHRIS (--); HU ZHIHOU (--); SCHIRMER ANDREAS (--); FRIEDMAN LISA (--); CARDAYRE STEPHEN B DEL (--); BRUBAKER SHANE (--); BERRY DAVID (--)
Industry:
Life Sciences
Inventor:
RACKHAM; OLIVER|Chin; Jason W.
Industry:
Life Sciences
Inventor:
Zhang; Zhiwen|Alfonta; Lital|Schultz; Peter
[EN] The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed t
Industry:
Energy
Inventor:
KOSURI SRIRAM (US); GREEN BRIAN (US); DEVROE ERIC (US); BERRY DAVID (US); AFEYAN NOUBAR (US); SKRALY FRANK (US); ROBERTSON DAN (US); RIDLEY CHRISTIAN (US)
Industry:
Research
Inventor:
Moon; Tae Seok|Yoon; Sang-Hwal|Prather; Kristala Lanett Jones
Industry:
Life Sciences
Inventor:
Suzuki; Yasuhiko|Yamamoto; Keiichi|Tahara; Hiroshi|Suzuki; Yusuke
Industry:
Research
Inventor:
JANTZ; Derek|NICHOLSON; Michael G.|SMITH; James J.
Industry:
Research
Inventor:
Lin; Shaoyang
Compositions and methods for the detection of vancomycin-resistant pathogens using primers and/or probes to the vanA and vanB genes.
Industry:
Pharma
Inventor:
BERGERON MICHEL G|BOISSINOT MAURICE|HULETSKY ANN|MENARD CHRISTIAN|OUELLETTE MARC|PICARD FRANCOIS J|ROY PAUL H
[EN] This invention provides compositions and methods for producing translatio nal components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA’s orthogonal amino acyl-tRNA syntheta
Industry:
Pharma
Inventor:
NORMAN THEA (US); TIAN FENG (US); CHU STEPHANIE (US)
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limi
Industry:
Pharma
Inventor:
SMITH JAMES JEFFERSON|JANTZ DEREK|HELLINGA HOMME W
[EN] Disclosed herein are non-natural amino acids and polypeptides that includ e at least one non-natural amino acid and methods for making such non-natur al amino acids and polypeptides. The non-natural amino acids by themselves or as a part of a polypep
Industry:
Pharma
Inventor:
MIAO ZHENWEI (US); LIU JUNJIE (US)
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not lim
Industry:
Life Sciences
Inventor:
LIU CHANG C|SCHULTZ PETER G
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limi
Industry:
Pharma
Inventor:
Smith; James Jefferson|Jantz; Derek|Hellinga; Homme W.
[EN] The invention provides a computer implemented process for constructing a scalable output network model of a bioparticle. The process includes computer implemented steps of: (a) accessing a database of network gene components including an annotated ne
Industry:
Pharma
Inventor:
SCHILLING CHRISTOPHE H (US)
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness
Industry:
Research
Inventor:
Cox; George N.|Doherty; Daniel H.|Rosendahl; Mary S.
[EN] Methods for the fermentive production of four carbon alcohols are provided. Specifically butanol preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorg
Industry:
Chemical
Inventor:
NAGARAJAN VASANTHA (US); ELIOT ANDREW C (US); DONALDSON GAIL K (US); NAKAMURA CHARLES E (US); HUANG LIXUAN L (US)
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these
Industry:
Pharma
Inventor:
NA
The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is particularly useful in the diagnosis of leishmaniasis, par
Industry:
Life Sciences
Inventor:
Bhatia; Ajay|Reed; Steven G.
Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specificall
Industry:
Research
Inventor:
Brentano; Steven T.|Lyakhov; Dmitry|Carlson; James D.|Nelson; Norman C.|Arnold, Jr.; Lyle J.