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Title:
A TARGETING SIGNAL FOR INTEGRATING PROTEINS, PEPTIDES AND BIOLOGICAL MOLECULES INTO BACTERIAL MICROCOMPARTMENTS
Number:
WO2011094765A2
Publication Date:
2011-08-04
Location:
USA
Priority Date:
IPC clasifications:
A61K 48/00; C07K 14/195
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor:
KERFELD, Cheryl, A.|KINNEY, James, N.
Class / subclass:
Applied Technologies / Technologies for integrating Biological Systems
Industry:
Life Sciences
Abstract:

A conserved region of sequence in bacterial microcompartment (BMC) enzymes and proteins was identified. Peptides derived from this conserved region of native BMC proteins and enzymes appear to target the hexameric facets of BMC shell proteins. These peptides were predicted to share general properties of a predicted alpha helical conformation, flanked by poorly conserved segment(s) of primary structure); for each type of encapsulated protein, and for each functionally distinct BMC. These peptides can be used as targeting signals for integrating biomolecules and molecules into bacterial microcompartments or for attaching molecules or biomolecules to native or non-native bacterial microcompartment shell proteins.

Claims:

NA

Patent Family:
WO2011094765A2 WO2011094765A3