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Title:
METHOD FOR SCREENING OF QUORUM SENSING INHIBITORS
Number:
WO2011055987A2
Publication Date:
2011-05-12
Location:
KR
Priority Date:
IPC clasifications:
C12N 15/52; C12N 15/63; G01N 33/15
Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor:
KIM, Hak-Sung|KIM, Jin-Hyun|LEE, Sang-Chul|JEONG, Young-Su
Class / subclass:
Base Technologies / Other biological chassis
Industry:
Research
Abstract:

The present invention relates to a vector comprising an expression cassette for screening quorum sensing inhibitors, which comprises a gene encoding a transcriptional regulator that recognizes and binds to acyl homoserine lactone, a gene encoding an inhibitor of antibiotic-degrading enzyme that is operably linked to a promoter regulated by the transcriptional regulator, and a gene encoding an antibiotic-degrading enzyme that is inhibited by the inhibitor of antibiotic-degrading enzyme, a method for screening a quorum sensing inhibitor and a quorum sensing inhibitor screened by the method.

Claims:

Patent Family:
KR2001141787B1 KR2011049193A WO2011055987A2 WO2011055987A3