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Title:
COMPOSITIONS AND METHODS FOR THE REGULATION OF MULTIPLE GENES OF INTEREST IN A CELL
Number:
WO2011053957A2
Publication Date:
2011-05-05
Location:
USA
Priority Date:
IPC clasifications:
C12N 15/63
Assignee:
Gen9, Inc.
Inventor:
JACOBSON, Joseph|CHURCH, George
Class / subclass:
Base Technologies / Genetic circuits and devices
Industry:
Research
Abstract:

Methods and compositions are provided for manipulating the genome of host cell to produce at least one exogenous gene product. Also provided are methods and composition for producing a programmable cell comprising a plurality of exogenous genes, wherein each exogenous gene is under the control of a disrupted regulatory sequence and wherein the disrupted regulatory sequences are restored by in vivo recombination. Preferably, the gene of interest is under the control of a genetically altered promoter which sequence recombination effects the expression of the exogenous gene(s).

Claims:

Patent Family:
US20120315670A1 WO2011053957A2 WO2011053957A3 WO2011053957C2 WO2011053957A9