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Title:
Host Cells and Methods for Producing 1-Deoxyxylulose 5-phosphate (DXP) and/or a DXP Derived Compound
Number:
US20130052692A1
Publication Date:
2013-02-28
Location:
USA
Priority Date:
IPC clasifications:
C12N 1/15; C12N 1/19; C12N 1/21; C12N 5/10; C12P 5/00; C12P 7/00; C12P 7/04; C12P 7/16; C12P 7/18; C12P 9/00; C12P 19/18
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor:
KIRBY JAMES|FORTMAN JEFFREY L|NISHIMOTO MINOBU|KEASLING JAY D
Class / subclass:
Applied Technologies / Other technologies for the biological synthesis of useful products / Other chemicals (organic acids, vitamins, etc)
Industry:
Chemical
Abstract:

The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phosphate and/or ribulose 5-phosphate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.

Claims:

A genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12) comprising: (a) a mutant RibB, or functional variant thereof, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.

Patent Family:
US20130052692A1