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Title:
BIOLOGICAL ANALOG-TO-DIGITAL AND DIGITAL-TO-ANALOG CONVERTERS
Number:
US20130009799A1
Publication Date:
2013-01-10
Location:
USA
Priority Date:
IPC clasifications:
H03M 1/12; H03M 1/66
Assignee:
TRUSTEES OF BOSTON UNIVERSITY|MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor:
COLLINS, James, J.|LU, Timothy Kuan-Ta
Class / subclass:
Base Technologies / Genetic circuits and devices
Industry:
Electronic
Abstract:

Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs to digital outputs, and digital inputs to analog outputs, in cells and cellular systems. Flexibility in these biological converter switches is provided by combining individual modular components, i.e., SIMMs and genetic toggle switches, together. These biological converter switches can be combined in a variety of network topologies to create circuits that act, for example, as switchboards, and regulate the production of an output product(s) based on the combination and nature of input signals received.

Claims:

An analog-to-digital biological converter switch, the biological converter switch comprising at least two modules, wherein each module comprises: an inducible promoter sequence (iPA), a repressor sequence (RA), and a toggle switch (TSA), (iPA-RA-TSA)n; wherein the toggle switch comprises a first repressible promoter sequence (rP 1 ) that drives expression of a second repressor sequence (R 2), and a second repressible promoter sequence (rP 2 ) that drives expression of a first repressor sequence (R 1 ), and an output sequence encoding an output product (OP) (rP 1 -R 2 and rP 2 -R1 -OP), wherein the first and second repressor sequences encode first and second repressor proteins respectively, and wherein the first repressible promoter sequence is inhibited by the first repressor protein and the second repressible promoter sequence is inhibited by the second repressor protein, and where n2

Patent Family:
US20130009799A1 WO2011066539A2 WO2011066539A3