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Title:
Compositions of Orthogonal Lysyl-tRNA and Aminoacyl-tRNA Synthetase Pairs and Uses Thereof
Number:
US20120129215A1
Publication Date:
2012-05-24
Location:
USA
Priority Date:
IPC clasifications:
C12N; C12N 9/00; C12P 21/00
Assignee:
The Scripps Research Institute
Inventor:
Anderson; J. Christopher|Wu; Ning|Santoro; Stephen|Schultz; Peter G.
Class / subclass:
Base Technologies / Cell machinery
Industry:
Research
Abstract:

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.

Claims:

NA

Patent Family:
AT386133E AT471385E AU4267359A1 AU4267359BB BRI0412272A CA2531146A1 CA2531146AA CN101076598A CN101076598B DE602004011789C0 DE602004011789T2 DE602004027770C0 EP1649004A2 EP1649004A4 EP1658366A2 EP1658366A4 EP1666604A1 EP1666604B1 EP1704242A2 EP1704242A4 EP