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Title:
[FR] ÉDITION DU GÉNOME D'UN LOCUS DE ROSA EN UTILISANT DES NUCLÉASES À DOIGT DE ZINC\[EN] GENOME EDITING OF A ROSA LOCUS USING ZINC-FINGER NUCLEASES\
Number:
WO2011139335A1
Publication Date:
2011-11-10
Location:
USA
Priority Date:
2010-04-26
IPC clasifications:
C12N 15/00; C12N 15/87
Assignee:
SANGAMO BIOSCIENCES INC (US); SIGMA ALDRICH COMPANY (US); CUI XIAOXIA (US); HOLMES MICHAEL C (US); DAVIS GREGORY (US); GREGORY PHILIP D (US); WEINSTEIN EDWARD J (US)
Inventor:
CUI XIAOXIA (US); HOLMES MICHAEL C (US); GREGORY PHILIP D (US); DAVIS GREGORY (US); WEINSTEIN EDWARD J (US)
Class / subclass:
Integration and development / Miroorganisms coding synthetic metabolic pathways
Industry:
Research
Abstract:

[EN] Disclosed herein are methods and compositions for genome editing of a Rosa locus using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided as are cells comprising said polynucleotides and fusion proteins.\[FR] La présente invention concerne des procédés et des compositions pour l’édition de génome d’un locus de Rosa en utilisant des protéines de fusion comprenant une protéine à doigt de zinc et un domaine de clivage ou un demi-domaine de clivage. La présente invention concerne en outre des polynucléotides codant pour lesdites protéines de fusion ainsi que des cellules comprenant lesdits polynucléotides et protéines de fusion.\

Claims:

A fusion protein comprising a nuclease and one or more engineered TALE repeat domains.

Patent Family:
AU9322964A1 AU10275432A1 CA2745031A1 CA2767377A1 CA2795636A1 CA2795643A1 CA2796600A1 CN102625655A CN102858985A CN102939377A CN102959078A CN102971421A EP2352369A1 EP2352369A4 EP2456877A1 EP2456877A4 EP2558574A1 EP2558575A1 EP2563918A1 IL217409A0 JP20125108