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Title:
Microorganisms and processes for enhanced production of pantothenate
Number:
US7291489
Publication Date:
2004-07-29
Location:
Germany
Priority Date:
2002-07-03
IPC clasifications:
Assignee:
Inventor:
Class / subclass:
Applied Technologies / Microorganisms coding synthetic metabolic/biochemical pathways
Industry:
Pharma
Abstract:

The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

Claims:

Patent Family:
US7244593